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KMID : 0390320130230010135
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Chungbuk Medical Journal
2013 Volume.23 No. 1 p.135 ~ p.141
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Clinico-metabolic Factors Determining the Urinary Oxalate Excretion
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Lee Sang-Cheol
Kang Ho-Won
Kim Won-Tae
Yun Seok-Joong
Kim Wun-Jae
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Abstract
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Purpose: Urinary oxalate is a key contributor to calcium oxalate crystallization and kidney stone formation. The purpose of the present study is to determine the clinico-metabolic factors for urinary oxalate excretion
Materials and Methods: A total of 1077 patients(693 men, 384 women) who were presented to our hospital for urinary stone disease from January 2001 to December 2011 were evaluated and their mean age was 446.4 years old. Serum and 24-hour urinary metabolic evaluation were performed at least one month after complete stone removal. The relationship between hyperoxaluria status and clinico-metaboic risk factors was analyzed.
Results: Hyperoxaluria that was defined by urinary oxalate excretion more than 40 mg per day was detected in 167 patients(15.6%). On urinary examination, metabolic abnormalities were hypocitraturia (46.4%), hypernatriuria(44.3%), hyperuricosuria(27.8%), hypercalciuria(19.1%), hypomagnesuria(7.0%) in order. In multivariate analysis, hypernatriuria and hypomagnesuria were significantly associated with urinary oxalate excretion(p=0.010 and 0.050, respectively).
Conclusion: Increased urinary excretion of sodium and decreased excretion of magnesium are associated with hyperoxaluria. Our date showed that dietary modification of sodium and magnesium might be effective for the recurrence prevention in patients with urolithiasis.
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KEYWORD
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Urinary calculi, Metabolic evaluation, Oxalate
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